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Pathological gambling PG is a relatively common and highly disabling impulse control disorder. A range of bupropion pathological gambling agents, including selective serotonin reuptake inhibitors, mood stabilizers, and opioid hambling, has been shown to be effective in the treatment of PG. The use of selective serotonin reuptake inhibitors and opioid antagonists buproion PG is consistent with the observation that PG shares features of both the obsessive-compulsive spectrum disorders and addictive disorders.
The aim of the study is to compare the effectiveness of sustained-release bupropion versus naltrexone in the treatment of PG. Thirty-six male pathological gamblers were enrolled in our study. A comprehensive psychiatric diagnostic evaluation was performed at baseline on all patients, and patients were screened for symptoms of gambling, depression, and anxiety using the Tioga downs casino website Oaks Gambling Screen, the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, and the Clinical Global Impression-Severity Scale.
In addition, the patients completed self-report questionnaires about their demographic bupropion pathological gambling. Treatment response was monitored using the Bupropion pathological gambling Global Apthological Scale which was performed at weeks 2, 4, 8, and Patients were also assessed for the presence of gambling behavior via an unstructured interview, which was also performed at weeks 2, bupropoon, 6, 8, and Raters were blind to the study treatment.
The majority of patients responded well to the drug treatment. Twelve of 17 patients in the sustained-release bupropion group completed the week study, and 13 of 19 naltrexone patients completed the study. Full response was defined buprooion the absence of gambling for a 2-week duration together with improvement on the Clinical Global Impression-Improvement Scale.
Partial response pathologicap defined as a decrease in the frequency of gambling behavior and a decrease in the amount of money spent on gambling. This preliminary study shows that sustained-release bupropion may be effective as naltrexone in the treatment of PG. Further studies are needed to confirm our findings. National Center for Biotechnology InformationU. Didn't get the message?
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